Mendelian randomization of leisure sedentary behavior, physical activity and scoliosis

Abstract

Abstract Objective: To investigate the relationship between leisure sedentary behavior (LSB), physical activity (PA) and the risk of scoliosis by using two-sample Mendelian randomization (MR). Methods: Genetic variation in television watching time, mobile phone use time, moderate-to-high intensity physical activity (MVPA), and vigorous physical activity (VPA) were used as instrumental variables, and genome-wide association data from a Finnish database of patients with scoliosis were used. The inverse variance weighting (IVW) method was used as the main analysis method, and the weighted median, MR-Egger, MR Multi-effect residual sum and outlier were combined to perform multiple sensitivity analysis. Results: IVW results showed: watching TV time (OR=0.623, 95%CI: 0.616-1.789, P=0.623); Time spent on mobile phones (OR=0.575, 95%CI: 0.169-1.960, P=0.377); MVPA (OR=0.535, 95%CI: 0.09-3.15, P=0.49); VPA (OR=0.623, 95%CI: 0.616-1.789, P=0.623). The results of the primary IVW MR Analysis were consistent with those of the multiple sensitivity MR Analysis. Conclusion: Genetic susceptibility to leisure sedentary behavior and physical activity are not associated with the risk of scoliosis. The observed associations may be the result of shared genetic effects or environmental confounding factors. However, we found a possible correlation between the type of physical activity and scoliosis.