Synthesis and initial in vitro evaluation of PSMA-targeted ligands with optimized structural motifs.-Reference-Cited by-同舟云学术

Synthesis and initial in vitro evaluation of PSMA-targeted ligands with optimized structural motifs.

Published:2022-09-02 Issue: Volume: Page:
ISSN:
Container-title:
language:
Short-container-title:

Author:

Uspenskaya Anastasia¹^ORCID,Nimenko Ekaterina¹,Shafikov Radik¹,Zyk Nikolay¹,Evteev Sergei²,Dashkova Natalia¹,Ivanenkov Yan²,Majouga Alexander³,Skvortsov Dmitry¹,Garanina Anastasiia⁴,Beloglazkina Elena¹,Machulkin Aleksei¹

Affiliation:

1. Moscow State University: Moskovskij gosudarstvennyj universitet imeni M V Lomonosova

2. Federal State Unitary Enterprise All-Russia Research Institute of Automatics named after N L Dukhov: FGUP Vserossijskij naucno-issledovatel'skij institut avtomatiki imeni N L Duhova

3. Dmitry Mendeleev University of Chemical Technology of Russia: Rossijskij himiko-tehnologiceskij universitet imeni D I Mendeleeva

4. National University of Science and Technology MISIS College of Mining: Nacional'nyj issledovatel'skij tehnologiceskij universitet MISiS Gornyj institut

Abstract

Abstract An improved series of ligands targeting prostatic specific membrane antigen (PSMA) has been reported. Varying compounds and their biological parameters were due to changes in the linker structure. Highly selective compounds with nanomolar IC50 values were obtained. As an example, a conjugate with Sulfo-Cy5 and MMAE was obtained and pre-studied.

Publisher

Research Square Platform LLC

Reference17 articles.

1. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries;Sung H,2021

2. Prostatic specific membrane antigen and its role in prostate cancer diagnosis;Chekhonin V;Quest Med Chem,2002

3. Expression of prostate-specific membrane antigen in tumor-associated vasculature predicts poor prognosis in hepatocellular carcinoma;Jiao D;Clin Transl Gastroenterol,2019

4. Synthesis and biological analysis of prostate-specific membrane antigen-targeted anticancer prodrugs;Kularatne SA;J Med Chem,2010

5. PSMA-targeted small-molecule docetaxel conjugate: Synthesis and preclinical evaluation;Machulkin AE;Eur J Med Chem,2022