Efficacy and Safety of Two Simplified Regional Citrate Anticoagulation for Intermittent Hemodialysis: A Randomized Cross-over Trial

Abstract

In recent years, due to the low risk of bleeding, regional citrate anticoagulation (RCA) is being tried for intermittent hemodialysis (IHD). Simplified regional citrate anticoagulation (S-RCA) has been attempted in IHD. This randomized cross-over trial was designed to compared the efficacy and safety of two RCAs in heparin-free dialysis patients, which were named S-RCA and two-stage simplified regional citrate anticoagulation (TS-RCA). In summary, the anticoagulation effect of TS-RCA is better than that of S-RCA in IHD, especially in the anticoagulation of venous bubbles trap. And these two RCAs were safe for IHD patient with high bleeding risk. Trial Registration: Chinese Clinical Trial Registry (CHICTR): Registration Number ChiCTR2000034314; Registration date 28 September 2020.