Highly Sensitive Photonic Crystal Fiber Biosensor Based on Surface Plasmon Resonance for Six Distinct Types of Cancer Detection

Abstract

Abstract An innovative photonic crystal fiber (PCF) biosensor using surface plasmon resonance (SPR) to diagnosis six distinct kinds of cancers (Skin cancer, Cervical cancer, Adrenal gland cancer, Blood cancer, Breast cancer type 1 and 2) in cells is demonstrated here, incorporates with two micro channels and a bimetallic configuration. The numerical analysis utilizes the finite element method (FEM) combined with perfectly matched layers (PML). The plasmonic material employed in the biosensor is gold (Au), and a supportive material, titanium dioxide (TiO2) is combined with Au. Through combining together these two materials, the sensor's performance is improved. The numerical calculations indicate that Breast Cancer Type 2 has the highest wavelength sensitivity 24285.71 nm/RIU, amplitude sensitivity 3959 RIU-1. Rest of the cancer cells wavelength sensitivities are 11000.00 nm/RIU (Skin Cancer), 13333.33 nm/RIU (Cervical Cancer), 15000.00 nm/RIU (Blood Cancer), 17142.85 nm/RIU (Adrenal-gland Cancer) and 21428.57 nm/RIU (Breast Cancer Type 1). This advanced biosensor has several uses in biological sensing and medical technology, and it has the potential to revolutionize cancer identification and medical diagnosis.