Structural evidence for direct connectivity between the human precuneus and temporal pole via the fifth subcomponent of the Cingulum.-Reference-Cited by-同舟云学术

Structural evidence for direct connectivity between the human precuneus and temporal pole via the fifth subcomponent of the Cingulum.

Published:2023-02-07 Issue: Volume: Page:
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Author:

Skandalakis Georgios P.¹,Komaitis Spyridon¹,Neromyliotis Eleftherios¹,Drossos Evangelos¹,Dimopoulos Dimitrios¹,Hadjipanayis Constantinos G.²,Kongkham Paul N.³,Zadeh Gelareh³,Stranjalis George¹,Koutsarnakis Christos¹,Kalyvas Aristotelis³

Affiliation:

1. University of Athens School of Medicine

2. University of Pittsburgh, UPMC

3. Toronto Western Hospital, University Health Network, University of Toronto

Abstract

Abstract Neuro-imaging studies demonstrate simultaneous activation of the human precuneus and temporal pole, both in resting-state conditions and during a diverse array of higher-order functions. Despite remarkable advances in neuroscience research, the precise underlying structural connectivity remains unclear. Here, we investigate the connectivity of the precuneus and temporal pole through fiber micro-dissections in human hemispheres. We show the direct axonal connectivity between the posterior precuneus area POS2 and the areas 35 and TI of the temporal pole via the fifth subcomponent of the cingulum. This finding enhances the neuroanatomical knowledge regarding the connectivity of the posteromedial cortices, facilitates the detailed anatomo-functional integration in normal and pathological brain function, and suggests an axonal connectivity unique within the human brain supporting the differences in neural networks between species.

Publisher

Research Square Platform LLC

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