Efficacy of Autologous Platelet Rich Plasma on Morphea: A Comparative Clinical and Ultrasonographic Follow-up Study

Abstract

Abstract Despite different modalities for morphea therapy used; it still has a great challenge. This study aimed to evaluate the efficacy and safety of intralesional Autologous Platelet Rich Plasma injection once weekly for 12 sessions to restore skin disfigurement (dyspigmentation, skin atrophy, and adnexal destruction) in nine patients (21 lesions) with a mean duration of 5.96 ± 2.4 years. The disease severity and damage were evaluated by the Localized Scleroderma Cutaneous Assessment Tool (LoSCAT) score; the skin layer thickness and Echogenicity were evaluated by musculoskeletal ultrasound at baseline, 3- month, and 6 months intervals. The LoSCAT score showed a significant improvement with the mean reduction from 13 ± 7.3 to 7.33 ± 6.8 at the end of 3rd month and to 6.44 ± 7.1 at the end of 6th month (p = 0.008 and 0.014) respectively, additionally, the ultrasound showed an increase in the thickness of skin layers from baseline to be nearly equal to normal control (p < 0.001), with transient adverse effects. The present study indicates that PRP is a good tool for the improvement of morphea lesions with a great aesthetic outcome.