Adjunction of doxazosin before ureterolithotripsy for improving successful access rate, a retrospective analysis

Abstract

Abstract Introduction To evaluate efciency and safety of adjunct doxazosin therapy before semi-rigid ureteroscopy and RIRS for urinary stones. Method We respectively analysis the data of patients who underwent semi-rigid ureterosocpy and RIRS. The patients were divided into four group: patient underwent semi-rigid ureterosocpy with or without doxazosin per-surgery; patients underwent RIRS with or without doxazosin per-surgery. The following information was analysis for each patient: age; gender; stone’s laterality, location, and maximal diameter; successful access rate; and surgery complications. Result Total of 246 patients were concluded in the fnal analysis. Mean age, gender, laterality, stone’s laterality, location and maximal diameter were similar among each groups. The successful rate of patients underwent semi-rigid ureterosocpy with doxazosin 5 days per-surgery was 95% when was 79.69% of pateints without doxazosin. And the successful rate of patients underwent RIRS with doxazosin 5 days per-surgery was 84.09% and when was 57.41% of pateints without doxazosin. Duration of double-J stent post-surgery and complication rates were similar among groups. Conclusion Doxazosin could be used safely and effectively before both semi-rigid and flexible ureteroscopy.