An update to the mSLAMB dialysis device (the “Kirpa Kit”): An in-vitro comparison of efficiency

Author:

Ceschia Giovanni1ORCID,Slagle Cara L2,Morgan Jolyn1,Snyder Amanda1,Rose James E1,Plute Ed3,Chawla Apaara K4,Coriolan Rebecca5,Soranno Danielle E2,Goldstein Stuart L1,Hasson Denise C5

Affiliation:

1. Cincinnati Children's Hospital Medical Center

2. Riley Hospital for Children at Indiana University Health

3. Stavro Medical Inc.

4. George Washington University

5. NYU Langone Health

Abstract

Abstract

Background Access to pediatric dialysis is challenged in low-resource settings by high costs, scarcity of equipment, and lack of qualified personnel availability. We demonstrated the manual Single Lumen Alternating Micro-Batch (mSLAMB) device can remove small solutes in vitro without the need for electricity, batteries or pumps. We developed a new version (Kirpa Kit™) to address some of the technical limitations of mSLAMB. Here we compare the in vitro clearance performance and ease of use of Kirpa Kit™ with that of prior mSLAMB configurations. Methods A mixture of expired packed red blood cells, 0.9% NaCl, urea and heparin was used to test the efficiency of two mSLAMB configurations and Kirpa Kit™ in removing potassium and urea. Clearance was evaluated by measuring percent reduction after 25-minute sessions with each device. A survey was used to evaluate the ease of use of each configuration. Results The Kirpa Kit™ achieved a median urea reduction of 82.4% and potassium reduction of 82.1%, which were higher than those achieved with the best-performing mSLAMB configuration (urea 71.9%, potassium 75.4%). The Kirpa Kit™ was easier to use with a shorter perceived time of use than the mSLAMB. Conclusions The Kirpa Kit™, evolution of mSLAMB, is easy to use and may have improved efficacy, making it an optimal candidate for in vivo testing.

Publisher

Springer Science and Business Media LLC

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