Association between triglyceride glucose index and heart failure with preserved ejection fraction in patients with coronary heart disease — a RCSCD-TCM study in China

Abstract

Abstract Background The triglyceride glucose (TyG) index serves as a surrogate indicator of insulin resistance. However, there is limited evidence on the association between the TyG index and heart failure with preserved ejection fraction (HFpEF) in patients with coronary heart disease (CHD). Methods The 62,794 CHD patients were included used to analyze the relationship between the TyG index and heart failure (HF) in CHD patients. Of these, 8,606 patients who underwent echocardiography were included to identify different types of HF, including HF with reduced ejection fraction (HFrEF), HF with intermediate-range ejection fraction (HFmrEF), and HFpEF. Logistic regression was used to analyze the relationship between the TyG index and HFpEF in CHD patients. The relationship between the TyG index and HFpEF according to sex, age, blood lipids and blood pressure states were also assessed. Results A baseline analysis of CHD patients divided into four groups according to the tertile level of the TyG index showed that there were significant differences in related parameters between the groups. In the multi-adjusted modles, the TyG index was significantly associated with the risk of HFpEF (OR: 1.56; 95% CI: 1.08–1.23). In addition, the TyG index of CHD patients was significantly associated with HFpEF in elderly (> 60 years old) patients (OR:1.19; 95% CI: 1.10–1.48), hypertension (OR:1.17; 95% CI: 1.10–1.25) and dyslipidemia (OR:1.16; 95% CI: 1.08–1.23). The association between the TyG index and HFpEF was not affected by sex. And the association between the TyG index of female and HFpEF was (OR:1.21; 95% CI: 1.10–1.34), which was higher than that of male (OR:1.11; 95% CI: 1.02–1.21). Conclusions This study demonstrated a significant association of the TyG index and HFpEF in CHD patients. In this study, the results show that the TyG index was independently associated with HFpEF in hypertension, dyslipidemia, and elder patients (> 60 years old). In addition, the association between the TyG index and HFpEF in CHD patients was higher in female.