Application of Magnetic Resonance Image Compilation (MAGiC) in the Diagnosis of Middle-Aged and Elderly Women with Osteoporosis

Abstract

Abstract Objective: To investigate the feasibility of diagnosing osteoporosis (OP) in women through magnetic resonance image compilation (MAGiC). Methods: A total of 110 patients who underwent lumbar magnetic resonance imaging and dual X-ray absorptiometry examinations were collected and divided into two groups according to age and bone mineral density: osteoporotic group (OP) and non-osteoporotic group (non-OP). The variation trends of T1 (longitudinal relaxation time), T2 (transverse relaxation time) and BMD(bone mineral density) with the increase of age, and the correlation of T1 and T2 with BMD were examined by establishing a clinical mathematical model. Results: With the increase of age, BMD and T1 value decreased gradually, while T2 value increased. T1 and T2 had statistical significance in diagnosing OP (P=0.000), and there is moderate positive correlation between T1 and BMD values (R=0.636, P=0.000), while moderate negative correlation between T2 and BMD values (R=0.694, P=0.000). Receiver characteristic curve test showed that T1 and T2 had high accuracy in diagnosing OP (T1 AUC=0.982, T2 AUC=0.978), and the critical values of T1 and T2 for evaluating osteoporosis were 0.625s and 0.095s, respectively. Besides, the combined utilization of T1 and T2 had higher diagnostic efficiency (AUC=0.985). Combined T1 and T2 had higher diagnostic efficiency (AUC=0.985). Function fitting results of OP group: BMD=-0.0037* age -0.0015*T1+0.0037*T2+0.86, sum of squared error (SSE) =0.0392, and non-OP group: BMD=0.0024* age -0.0071*T1+0.0007*T2+1.41, SSE=0.1007. Conclusion: T1 and T2 value of MAGiC have high efficiency in diagnosing OP by establishing a function fitting formula of BMD with T1, T2 and age.