Affiliation:
1. Suiyukai Clinic
2. Kurume University School of Medicine
Abstract
Abstract
Background
Soluble transferrin receptor (sTfR) was reported to be a valuable diagnostic marker for functional iron deficiency (FID). Hepcidin, which is a key regulator of iron metabolism, has been shown to have increased values in patients undergoing hemodialysis (HD). Thus, we measured serum levels both of sTfR and hepcidin in 97 HD patients and investigated the clinical value of these measures.
Methods
We used a commercial enzyme-linked immunosorbent assay kit to measure serum levels both of hepcidin and sTfR.
Results
Although serum sTfR levels did not clearly increase, both sTfR levels and its index value correlated with the saturation of transferrin, erythropoietin-stimulating agent dosage, and erythropoietin resistance index (ERI). In addition, a strong negative correlation was found for sTfR and log serum hepcidin values.
Conclusions
Serum sTfR levels and the sTfR index were acceptable markers for FID and ERI even in patients undergoing HD whose serum levels of hepcidin increased.
Publisher
Research Square Platform LLC
Reference24 articles.
1. Gerhard Rogler, Clara Camaschella, Rezan Kadir. Iron deficiency across chronic inflammatory conditions: International expert opinion on definition, diagnosis, and management;Cappellini MD;Am J Hematol,2017
2. Goodnough. Anemia of inflammation;Guenter Weiss T;Blood,2019
3. Circulating transferrin receptor in human serum;Kohgo Y;Br J Haematol,1986
4. T Numata,T Nishisato,I Urushizaki. Serum transferrin receptor as a new index of erythropoiesis;Kohgo Y;Blood,1987
5. Biochemical markers and hematologic indices in the diagnosis of functional iron deficiency;Thomas C;Clin Chem,2002