Affiliation:
1. Federal University of Amazonas
Abstract
Abstract
This project was designed to evaluate whether people living with HIV (PLHIV) on HAART, hospitalized, with weight loss, have higher mortality than those hospitalized using HAART and without weight loss. It was a meta-analysis of prospective cohort studies published in English, Spanish or Portuguese. We searched MedLine, Embase, and LILACS and conducted the report according to MOOSE. We analyzed methodological quality and risk of bias by the Joanna Briggs Institute's Critical Assessment Tool for Cohort Studies, used the risk ratio (RR) to calculate the probability of hospitalized PLHIV who lost weight evolve to death, applied the random effect model, and created the funnel chart. Ten of the 670 studies identified were included for analysis, with a total of 1,637 PLHIV. We used the inverse test of variances estimated by the Mantel-Haenszel method, considering a 95% confidence interval, heterogeneity (I2), total effect size (Z), and a significance value of p < 0.05. The risk of hospitalized PLHIV who lost weight dying was 1.5 times greater than that of hospitalized PLHIV who did not lose weight (RR: 1.50, 95% CI: 1.03, 2.19, p = 0.04). We conclude that weight is still a determinant of mortality in PLHIV, even those on HAART. Prospero registration number: CRD42020191246
Publisher
Research Square Platform LLC
Reference41 articles.
1. 1. Chen X, Yu B, Zhao L. The evaluation of global epidemic of HIV/AIDS with a novel approach using country-specific counts of HIV infections and three rates controlled for population and geographic area. J Glob Health. 2019;3(3):66–67. doi: 10.1016/j.glohj.2019.09.002
2. 2. World health statistics 2022: monitoring health for the SDGs, sustainable development goals. Geneva: World Health Organization; 2022. Licence: CC BY-NC-SA 3.0 IGO
3. 3. Deeks SG, Lewin SR, Havlir DV. The end of AIDS: HIV infection as a chronic disease. The Lancet. 2013; 382, Issue 9903: 1525–1533. ISSN 0140–6736, https://doi.org/10.1016/S0140-6736(13)61809-7
4. 4. (https://www.sciencedirect.com/science/article/pii/S0140673613618097)Rein SM, Lampe FC, Johnson MA, Bhagani S, Miller RF, Chaloner C, Phillips AN, Burns FM, Smith CJ. All-cause hospitalization according to demographic group in people living with HIV in the current antiretroviral therapy era. AIDS. 2021 Feb 2;35(2):245–255. doi: 10.1097/QAD.0000000000002750. PMID: 33170817; PMCID: PMC7810421
5. 5. Steinhart CR. HIV-associated wasting in the era of HAART: a practice-based approach to diagnosis and treatment. AIDS Read. 2001 Nov;11(11):557 − 60, 566-9. PMID: 11789018