Procalcitonin and interleukin-6 in predicting prognosis of sepsis patients with cancer

Abstract

Abstract Objective: To evaluate the ability of infection indicators to predict the prognosis of sepsis patients with tumor. Methods: A total of 317 patients admitted to ICU from January 1, 2021 to June 30, 2021 were enrolled. Among them, 163 patients were infected during peri-operative period, and 98 patients were ultimately diagnosed with sepsis. The infection indicators were analyzed forprediction of sepsis prognosis. Results: Comparison of infection indicators between sepsis and non-sepsis patients showed that procalcitonin (PCT) and interleukin-6(IL-6) showed significant changes in sepsis patients, and PCT combined with IL-6 could significantly improve specificity of early screening for sepsis and have highest positivity predictive value for sepsis. Peak value combination of PCT and IL-6 could achieve high specificity to predict poor prognosis. Peak value combination of PCT and IL-6 for prediction specificity, positive predictive value and negative predictive value was 0.935, 0.692, and 0.682 respectively. Conclusion:Abnormal increase of PCT and IL-6 has a good early warning effect on sepsis in cancer patients, and the combination of PCT and IL-6 can improve predictive specificity and increase positive predictive ability of sepsis diagnosis. PCT combined with IL-6 shows the value in predicting the prognosis of sepsis patients with cancer.