Abstract
Background
Viral hemorrhagic fevers are a group of clinically similar diseases characterized by a spectrum of acute febrile syndromes ranging from mild to severe, accompanied by vascular damage, plasma leakage, and bleeding. The pathogenesis of viral hemorrhagic fevers is very complex and it related to lipidome.
Methods
In this study, we used 179 lipidomes as exposures and viral hemorrhagic fevers as the outcome. We primarily utilized MR-IVW, co-localization analysis and reverse MR analysis methods for analysis.
Results
Our study identified significant causal relationships between lipidomes and viral hemorrhagic fevers. Sterol ester (27:1/20:5) level(OR[95%CI] = 0.777[0.668,0.904],P = 0.042),phosphatidylcholine(16:0_20:4) level(OR[95%CI] = 0.788[0.689,0.902],P = 0.044),and phosphatidylcholine(O-18:0_20:4) level(OR[95%CI] = 0.745[0.625,0.887],P = 0.05) have a protective effect on viral hemorrhagic fevers.
Conclusions
Our MR analysis results indicate a causal relationship between specific lipidomes and viral hemorrhagic fevers.