Abstract
Background:The objective of this study was to elucidate the relationship between non-alcoholic fatty liver disease (NAFLD) and the triglyceride glucose-waist to height ratio (TyG-WHtR), and to ascertain its predictive value for the occurrence of NAFLD.
Methods: Data was collected from the National Health and Nutrition Examination Survey(NHANES) from March 2017 to March 2020. Age,Gender,Height, Weight, Waist circumference(WC),Hip circumference(HC), Body mass index(BMI), Fasting blood glucose(FBG),Triglycerides(TG),High-density lipoprotein cholesterol(HDL-C),Low-density lipoprotein cholesterol(LDL-C) and Controlled attenuation parameter(CAP)of the 3674 subjects were collected. The logistic regression analysis was performed to estimate associations between the waist-to-height ratio (WHtR) ,waist-hip ratio (WHR),the triglyceride glucose (TyG) index,the triglyceride to high-density lipoprotein cholesterol(TG/HDL-C) ratio, and TyG-WHtR with a diagnosis of NAFLD. The diagnostic performance of WHtR, WHR, TyG index, TG/HDL-C ratio and TyG-WHtR for cirrhosis was evaluated by receiver operating characteristic curve (ROC) analysis.
Results: The prevalence rates of NAFLD progressively increased across the quartiles of WHtR, WHR, TyG index, TG/HDL-C ratio and TyG-WHtR (P for tend < 0.0001).After adjusting for confounders, the TyG-WHtR had a better association with NAFLD risk than other indices.The odds ratios (ORs) of NAFLD from the second to the fourth quartiles of TyG-WHtR compared to the first quartile were 1.58 (1.16, 2.14), 1.84 (1.16, 2.93), and 2.15 (1.06, 4.37), respectively. The TyG-WHtR curve's area under the curve (AUC) was 0.823 (0.809, 0.837).the highest of all other study parameters.
Conclusions: Compared to WHtR, WHR, TyG index and TG/HDL-C ratio, TyG-WHtR was a more effective predictor of NAFLD. TyG-WHtR has the potential to be a simpler, more accurate, and more cost-effective non-invasive marker for predicting NAFLD patients.