Affiliation:
1. Tong Ji University School of Medicine
2. ShanghaiTech University
3. Changxing People’s Hospital of Zhejiang Province
Abstract
Abstract
Despite the high prevalence of ovarian cyst, its origin is still under debate. Prevailing retrograde menstruation model predicts that ectopic endometrial cells migrate and develop into ovarian cysts. However, other models were also proposed. Because DNA methylation states exhibit a tissue specific pattern, we profiled the DNA methylation for ovarian cysts and paired eutopic endometrial and ovarian tissues from four patients. Surprisingly, DNA methylation profiles showed the ovarian cysts were closely grouped with normal ovarian but not endometrial tissues. These results suggested alterative origin of ovarian cysts or strong epigenetic reprogramming of infiltrating endometrial cells after seeding the ovarian tissue.
Publisher
Research Square Platform LLC