Affiliation:
1. General Hospital of Ningxia Medical University
2. Ningxia Medical University
Abstract
Abstract
Objective: The aim of this study was to explore the accuracy and consistency between frozensection (FS) and final paraffin sections (PS) in a series of surgically resected early endometrial cancer (EC).
Materials and Methods: Data from 292 patients who underwent surgery for early EC between 2015 and 2021were retrospectively analyzed. The consistency of FS and PS on tumor grade and myometrium invasion (MI) depth of EC were analyzed and compared.
Results: Compared with PS, the consistency test (Ka) of FS in early EC tumor grade was Kappa statistic=0.789(P<0.001 ). The consistency of MI <50% and ≥50% was 94.96% and 64.81%, respectively (Ka=0.629, P<0.001 )The sensitivity, specificity, positive predictive value, and negative predictive value of the depth of MI during FS were 94.96%,64.81%,92.24%,74.47%, respectively. In addition, 38 cases were diagnosed as atypical hyperplasia and local canceration (AHLC) before surgery, which was finally confirmed as EC by FS and PS.
Conclusion: The early-stage EC tumor grade and the depth of MI can more accurately be classified based on FS, which can also provide high guiding value for lymph node dissection in early EC surgery.
Publisher
Research Square Platform LLC