Abstract
Objectives
This study employed Mendelian randomization to investigate the potential causal relationship between ulcerative colitis and nephrotic syndrome
Methods
We obtained the whole-genome association study data of ulcerative colitis in the European population from the GWAS database. Relevant single nucleotide polymorphisms (SNPs) were selected for analysis. We employed the inverse variance-weighted meta-analysis of multiplicative random effects models to obtain SNP-specific Wald ratio estimates, which assume horizontal pleiotropy. In addition, we performed sensitivity analyses using MR-Egger, weighted median, and IVW.
Results
Our findings suggest a strong association between ulcerative colitis and nephrotic syndrome(P < 0.05). After conducting sensitivity analyses, we found no evidence of horizontal pleiotropy or heterogeneity(P > 0.05).
Conclusion
Our Mendelian randomization study provides evidence for an association between ulcerative colitis and nephrotic syndrome, which may help us better understand the conditions of ulcerative colitis and nephropathy, as well as their relationship.