Analysis of risk factors for the early death of lymphocyte subsets in adult patients with secondary hemophagocytic lymphohistiocytosis

Abstract

Background Hemophagocytic lymphohistiocytosis (HLH) is an excess inflammatory response syndrome caused by genetic or acquired immune dysregulation. Method We examined the expression levels of lymphocyte subsets in the peripheral blood of 96 patients with sHLH. Result This study found that CD3-CD16 + CD56 + cells < 2% and CD3 + cells < 50% were important risk factors for early mortality in sHLH patients. Furthermore, age ≥ 55 years and Hemoglobin(HGB)< 70g/L were also found to be risk factors for early mortality in sHLH patients, which is consistent with many previous studies and may indicate that our results are credible. Conclusion Taken together, our results suggest that the reduction of CD3-CD16 + CD56 + cells and CD3 + cells are important risk factors for early mortality in patients with sHLH. This may provide new clues for the clinical prognosis of patients with sHLH.