Affiliation:
1. Inonu University School of Medicine
2. Malatya Turgut Ozal University School of Medicine
Abstract
Abstract
Purpose
Evaluation of corneal endothelial layer in patients with Hashimoto's thyroiditis (HT) by specular microscopy
Methods
This prospective cross-sectional study was carried out with 50 patients with Hashimoto's thyroiditis (group 1) and 44 healthy subjects (group 2) as controls. Endothelial cell density (ECD), hegzogonality (HEX), coefficient of variation (CV), central corneal thickness (CCT), minimum-maximum and mean cell volume (min-max MCV) were evaluated by noncontact specular microscope (Konan Medical Inc., Nishinomiya, Japan).
Results
The mean ages of the patients in group 1 and group 2 were 38.42 ± 9.70 and 38.18 ± 10.96 years, respectively. There was no significant difference between the two groups in terms of age and gender distribution (p > 0.05). HEX ratio (44.98 ± 5.86) and min-MCV values (149.82 ± 15.01) were statistically significantly lower in group 1 (p˂0.05). No significant difference was observed in other parameters evaluated by specular microscopy (p > 0.05).
Conclusion
The detection of thyroid hormone receptors in orbital structures and corneal layers suggests that the corneal endothelial layer may be affected and that structural or functional changes may occur in this layer in patients with HT.
Publisher
Research Square Platform LLC
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