Affiliation:
1. yokohama minami kyousai hospital
Abstract
Abstract
Oxaliplatin is a platinum-based anticancer therapy that causes less frequent kidney injury than conventional drugs, such as cisplatin. Previous reports of oxaliplatin-induced renal injury occurred after the patients had received multiples doses of the drug. In this study, a 75-year-old man with unknown primary cancer and underlying chronic kidney disease developed acute renal failure after receiving the first dose of oxaliplatin. Suspected of having drug-induced renal failure through an immunological mechanism, the patient was treated with steroids; however, the treatment was ineffective. Renal biopsy ruled out interstitial nephritis and revealed acute tubular necrosis (ATN). Renal failure was irreversible, and the patient subsequently required maintenance hemodialysis. This is the first case wherein renal biopsy results showed ATN despite a single oxaliplatin administration, and the renal dysfunction was irreversible, leading to maintenance dialysis.
Publisher
Research Square Platform LLC
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