Association between systemic inflammatory response index and abdominal aortic calcification

Abstract

Abstract Background Systemic inflammatory response index (SIRI), a valuable marker which indicates the inflammatory condition in the human body, has drawn more attention recently. Nevertheless, the correlation between SIRI and abdominal aortic calcification (AAC) has never been reported. The aim of this study was to explore the association between SIRI and AAC. Methods We utilized cross-sectional data sourced from the 2013–2014 National Health and Nutrition Examination Survey (NHANES) in this study. Multivariable linear regression models were employed to investigate the independent association between AAC and SIRI. Interaction test and subgroup analysis were conducted as well. Fitted smoothing curves were also applied to depict the nonlinear relationship. Results 3047 representative participants > 40 years of age were included in this study. Those in the higher quartile of SIRI demonstrated a tendency toward higher mean AAC scores and an elevated risk of severe AAC. A positive correlation emerged between SIRI and ACC scores, as well as the risk of severe AAC (β = 0.18, 95% CI 0.01–0.35; OR = 1.23, 95% CI 1.01–1.51) in the fully adjusted model. No significant dependence on the correlation of SIRI and AAC was revealed by the subgroup analysis and interaction tests. Conclusion Our investigation revealed a positive association between SIRI and AAC. This suggests that SIRI could be a potential clinical marker for identifying the presence and severity of AAC.