The Carboxymethyl cellulose-based slimming gel containing nano-liposomes loaded with chili pepper and ginger extracts: As destroyer jelly of obesity

Abstract

Abstract Obesity is a major global health issue that negatively impacts individuals and societies. It can lead to obesity-related illnesses, reduced quality of life, and even death. Diet, exercise, and surgery are basic solutions to overcome obesity, but due to the long duration of the treatment and sometimes the lack of appropriate results, create limitations. In this study for the first time, Carboxy methyl cellulose-based slimming gel containing nanoliposomes loaded chili pepper and ginger extracts (CMC-sliming gel containing Chi/G-NLPs), as bioactive fat burners, has been investigated for potential application in the fat burning and weight loss. Finally produced Nano-Gel (Ch/G-NLPs-CMC) were confirmed through scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), dynamic light scattering (DLS), Zeta potential, in vitro release profile and in vitro skin absorption assays. In vitro skin absorption assay showed 30% after 2.5 h use of CMC-sliming gel containing Chi/G-NLPs. In addition, the CMC-sliming gel containing Chi/G-NLPs size was 156 nm. In vitro release behavior of CMC-sliming gel containing Chi/G-NLPs showed slow control released at 24 h then a sharp peak release observed at 48 h. Our result confirmed the synergistic effect of chili pepper and ginger in the Nano-Gel platform, as a novel topical treatment, for eliminating local fat and a destroyer jelly of obesity.