A mega-analysis of vertex and gyral cortical thickness differences in adults with and without PTSD-Reference-Cited by-同舟云学术

A mega-analysis of vertex and gyral cortical thickness differences in adults with and without PTSD

Published:2022-10-06 Issue: Volume: Page:
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Author:

Xie Hong¹,O'Leary Erin^ORCID,Shih Chia-Hao²^ORCID,Cotton Andrew,Wall John,Chen Tian,Liu Rong,Xu Kevin,Abdallah Chadi³^ORCID,Andrew Elpiniki,Baird C. Lexi^ORCID,Baugh Lee,Bomyea Jessica,Bruce Steven,Bryant Richard⁴^ORCID,Choi Kyle,Daniels Judith,Davenport Nicholas,Davidson Richard⁵^ORCID,De Bellis Micheal,Dennis Emily⁶^ORCID,deRoon-Cassini Terri⁷^ORCID,Disner Seth,Fani Negar⁸^ORCID,Fercho Kelene,Fitzgerald Jacklynn,Forster Gina,Frijling Jessie,Geuze Elbert⁹^ORCID,Gomaa Hassan,Gordon Evan,Grupe Daniel¹⁰^ORCID,Harpaz-Rotem Ilan¹¹^ORCID,Haswell Courtney,Herzog Julia¹²^ORCID,Hofmann Davia,Hollifield Micheal,Hosseini Bobak,Hudson Anna^ORCID,Ipser Jonathan,Jahanshad Neda¹³,Jovanovic Tanja¹⁴,Kaufman Milissa¹⁵,King Anthony,koch Saskia¹⁶^ORCID,Koerte Inga¹⁵^ORCID,Koopowitz Sheri-Michelle,Korgaonkar Mayuresh¹⁷^ORCID,Krystal John¹⁸^ORCID,Larson Christine¹⁹,Lebois Lauren²⁰^ORCID,Levy Ifat²¹^ORCID,Li Gen,Logue Mark,Magnotta Vincent²²^ORCID,Manthey Antje,May Geoffrey,McLaughlin Katie,Mueller Sven^ORCID,Nawijn Laura^ORCID,Nelson ,Neria Yuval,Nitschke Jack²³,Olff Miranda²⁴^ORCID,Olson Elizabeth²⁵,Peverill Matthew^ORCID,Phan K Luan²⁶,Rashid Faisal,Ressler Kerry²⁰^ORCID,Rosso Isabelle,Salminen Lauren,Sambrook Kelly,Scheffler Freda^ORCID,Schmahl Christian²⁷,Shenton Martha²⁸,Sierk Anika,Simons Jeffrey,Simons Raluca,Sponheim Scott²⁹^ORCID,Stein Dan³⁰^ORCID,Stein Murray³¹^ORCID,Stevens Jennifer³²^ORCID,Straube Thomas³³,Suarez-Jimenez Benjamin³⁴,Tamburrino Marijo^ORCID,Thomopoulos Sophia,Wee Nic van der,Werff Steven van der,Erp Theo van³⁵^ORCID,Rooij Sanne van⁸^ORCID,Zuiden Mirjam van³⁶,Varkevisser Tim,Veltman Dick,Vermeiren Robert³⁷,Walter Henrik³⁸^ORCID,Wang Li^ORCID,Zhu Xi³⁹^ORCID,Zhu Ye,Thompson Paul⁴⁰,Wang Xin¹^ORCID,Morey Rajendra⁴¹,Liberzon Israel⁴²^ORCID

Affiliation:

1. University of Toledo

2. The University of Toledo

3. Baylor College of Medicine

4. UNSW Sydney

5. University of Wisconsin–Madison

6. University of Utah

7. Medical College of Wisconsin

8. Emory University

9. Utrecht University

10. University of Wisconsin-Madison

11. Yale University

12. Central Institute of Mental Health Mannheim, Medical Faculty Mannheim, Heidelberg University

13. University of Southern California

14. Wayne State University

15. Harvard Medical School

16. Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen

17. Westmead Institute for Medical Research

18. Yale University School of Medicine

19. University of Wisconsin-Milwaukee

20. McLean Hospital

21. Yale School of Medicine

22. University of Iowa

23. univeristy of wisconsin

24. Amsterdam UMC - Academic Medical Center

25. McLean Hospital, Harvard Medical School

26. The Ohio State Univeersity

27. Central Institute of Mental Health

28. Harward/BWH

29. Minneapolis VA Health Care System

30. University of Cape Town

31. University of California San Diego

32. Emory University School of Medicine

33. University of Münster

34. University of Rochester

35. University of California, Irvine

36. Amsterdam University Medical Centers, Amsterdam University Medical Centers, Location Academic Medical Centers, Amsterdam Neuroscience, University of Amsterdam

37. Curium-LUMC, Department of Child and Adolescent Psychiatry, Leiden University Medical Center in Oegstgeest, The Netherlands

38. Department of Psychiatry and Psychotherapy CCM, Charite - Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health, Be

39. Columbia University Medical Center

40. Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, California, USA

41. Duke University

42. University of Michigan

Abstract

Abstract A number of studies of posttraumatic stress disorder (PTSD) report thinner cerebral cortical gyri using gyrus-based analysis or thinner foci within the gyri using vertex-based analysis. However, the locations of these findings are inconsistent across studies, and the spatial transformations required during vertex-based analysis may affect the focal findings. A mega-analysis using a large number of subjects from multiple PTSD studies could potentially identify more reproducible cortical thickness abnormalities. Investigating both the vertex and gyral thicknesses simultaneously may verify the vertex-based focal findings using gyral data without imposing any spatial transformation. Here we aggregated data from 24 international laboratories using ENIGMA standardized procedures for 949 adult PTSD patients and 1493 controls without PTSD (age 18 to 65 years). We examined whether gyral and vertex cortical thickness are (a) different between subjects with PTSD and controls and (b) associated with PTSD symptom severity in trauma-exposed subjects. Regions with overlapping thinner cortical gyri and thinner vertex clusters were located in frontal, temporal, parietal, and occipital cortices. Thinner right lateral orbitofrontal and right lingual gyri and concomitantly thinner vertex clusters in the anterior portions of both gyri were associated with PTSD symptom severity. Convergent findings in these locations suggest focally thinner cortex in these gyri, which may be involved in altered processing and regulation of emotion and sensory inputs underlying posttraumatic stress symptoms.

Publisher

Research Square Platform LLC

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