Formulation of an Anti-inflammatory Pharmaceutical Drinkable Emulsion Based on Artemisia Absinthium L Essential Oil

Abstract

Abstract The importance of aromatic plants, their essential oil content and the chemical nature of their constituents, give them great prospects for application. Nowadays, essential oils present a major source of a variety of bioactive molecules, they are also used as an alternative to conventional drugs. The evaluation of phytotherapeutic properties, such as antioxidant, antimicrobial and anti-inflammatory are gaining great interest in the research field. The objective of this work is the evaluation of the antibacterial, antifungal and anti-inflammatory effect of the essential oil of wormwood from the region of Blida, Algeria and that of a drinkable emulsion formulated in the presence of this essential oil. Average yield of 0.52% of essential oil extracted by hydrodistillation using a Clevenger from the fresh aerial part of absinthe was obtained. GC/MS analysis demonstrated that wormwood essential oil is dominated by the presence of the compounds βThujone with 45.646% and 7-ethyl, 1,4 dimethyl Azulene with a percentage of 25.95%. The absinthe essential oil extracted showed an activity against all bacteria and fungi tested. The drinkable emulsion exerted remarkable an anti-inflammatory activity which induced an edema reduction rate of 35.70%, close to the one obtained by a Clofenal reference. Toxicity tests of the essential oil of Artemisia absinthium and the drinkable emulsion which were followed for two weeks, showed neither mortality nor abnormality.