Comparative study of surgical management for medication-related osteonecrosis of the jaws

Abstract

Purpose The aim of the trial was to assess whether the use of platelet-rich plasma (PRP) improves surgical outcomes for medication-related osteonecrosis of the jaw (MRONJ) compared with treatment without PRP. Methods We evaluated the clinical outcomes of two surgical treatment modalities for MRONJ. Group 1 (15 patients/18 sites with MRONJ) underwent bone resection with platelet-rich plasma (PRP). Group 2 (16 patients/18 sites with MRONJ) underwent bone resection without the use of PRP. We analyzed the medical records of patients in both groups. The following information was collected: Patient age and sex, primary tumour/disease, type and duration of bisphosphonate, clinical staging of MRONJ, outcome of surgical treatment. Results There was no significant difference in treatment success between the groups (p = 0.221). No significant differences were found for other variables (duration of drug use, gender, clinical stage). Conclusion These results definitively show that the use of PRP at the surgical site is not a critical factor in the successful treatment of MRONJ.