Exploring the factors influencing adherence to oral anticancer drugs in patients with digestive cancer: a qualitative study

Author:

NIZET Pierre1ORCID,TOUCHEFEU Yann1,PECOUT Solange1,CAUCHIN Estelle1,BEAUDOUIN Eva1,MAYOL Séverine1,FRONTEAU Clémentine1,HUON Jean-François1

Affiliation:

1. CHU Nantes: Centre Hospitalier Universitaire de Nantes

Abstract

Abstract Purpose The aim of this study was to explore the beliefs, perceptions and representations of patients in order to identify the determinants of oral anticancer drugs adherence and to take action in current practice to improve patient support in digestive oncology. Methods We constructed a semi-directed interview guide which aimed to explore the patient's relationship with medication, their health history, their experiences at the time of the announcement of treatment, their confidence, their fears, their motivations to adhere to their treatment and the constraints linked to their treatment. The data were analysed and discussed using a thematic approach. Results Seventeen patients agreed to participate in the study. The median age was 60 years. Ten patients had colorectal cancer, 3 patients had hepatocellular carcinoma, 3 patients had gastrointestinal stromal tumour and 1 patient had neuroendocrine pancreatic tumor. We identified five categories of factors influencing adherence: demographic and socioeconomic, disease-related, treatment-related, care system-related, and patient representation and pathways’ factors. A majority of patients emphasised the importance of family support in the adherence process and the convenience of per-os treatment compared to other intravenous treatments. However, several negative determinants emerged such as the toxicity of the treatment, fears of forgetting to take the medication, difficulties with the galenic formulation and negative beliefs of the family. Conclusion This study demonstrates the need to address the different dimensions of the patient in order to understand his or her behaviour with regard to adherence and to identify the levers for improvement.

Publisher

Research Square Platform LLC

Reference48 articles.

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3. Beauvais C. Quand prescrire ne suffit plus… L’observance thérapeutique: un enjeu pour les rhumatologues – Adherence to medication: a challenge for patients and rheumatologists. É ditorial. déc 2007;4

4. Adhésion, observance et persistance thérapeutiques: de quoi parle-t-on ? [Internet]. WeLL (2018) [cité 21 mars 2021]. Disponible sur: http://well-livinglab.be/adhesion-observance-persistance-therapeutique-de-quoi-parle-t-on/

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