Optimization, synthesis, and characterization of co-electrospinning cellulose acetate/thermoplastic polyurethanes composite membrane for photodynamic antibacterial application

Abstract

Abstract Photodynamic antibacterial composite membranes were engineered by integrating photosensitizer/ antibacterial agent, into the polyurethane adhesive blend and coating the blend on co-electrospinning cellulose acetate(CA)/thermoplastic polyurethanes(TPU) composite membrane support for enhanced antibacterial performance. The central composite design (CCD) method based on the response surface method (RSM) was used for analysis to illustrate the influence of important variables. The optimized parameters of CCD were TPU (wt%) 22.64%, CA (wt%) 18.63, DMAC/acetone volume ratio 0.85, LiCl (wt%) 0.95%, voltage (kV) 23.33kV. Fiber diameter was the key response process output variable. The membranes were characterized by SEM, XPS, and molecular structure analyses. The model had excellent applicability as a tool to realize the average diameter of the CA/TPU bicomponent electrospun membrane. Results showed that after coating, the synergistic effects of photodynamic antibacterial and antibacterial agent performance on the Antibacterial composite membrane were achieved under ordinary daylight irradiation. The sterilization rate of S. aureus and E. coli could achieve excellence at 99.2% and 93.4%, respectively. This method of preparing photodynamic antibacterial composite film provides a new direction for the design of medical antibacterial protective materials.