Abstract
Background
Hyperuricemia (HUA) has emerged as a significant metabolic disease, particularly in young population with metabolic syndrome (MS). The purpose of this study was to study the prevalence of HUA and its correlation with metabolic syndrome among young adults in a coastal city of eastern China.
Methods
It was a cross-sectional study conducted in adults undergoing routine healthy checkup. Anthropometric data and serological parameters were collected and in related to serum uric acid (SUA) concentration and prevalence of HUA.
Results
A total of 9,196 adults with mean age of 34.3 ± 11.8 years old and 75.2% of males were recruited. Mean SUA level was 371.8 ± 95.6 µmol/l and overall HUA prevalence was 31.3%. SUA level was higher and HUA was more common in younger males, as well as in those with MS (OR: 3.07; 95% CI: 2.78–3.39) demonstrated by using the univariable binary logistic regression analysis model. The multivariable binary logistic regression analysis revealed that male (OR: 3.74; 95% CI: 3.12–4.48), young age (OR: 1.22; 95% CI: 1.19–1.26), low estimated-glomerular filtration rate (OR: 2.45; 95% CI: 2.11–2.84), high body mass index (OR: 2.31; 95%CI: 2.06–2.60), hypertension (OR: 1.18; 95% CI: 1.04–1.32), high serum triglyceride (OR: 2.08; 95%CI: 1.81–2.37), and low serum high-density lipoprotein cholesterol (OR: 1.33; 95% CI: 1.15–1.55) were independent risk factors associated with HUA prevalence.
Conclusion
SUA level increased and HUA was common in young adults. Male, young age, reduced kidney function, combined with MS and more MS components were associated with prevalence of HUA.