Affiliation:
1. São Paulo State University (UNESP)
2. Amazonas State University (UEA)
Abstract
Abstract
Objective
Isotretinoin, also known as 13-cis-retinoic acid, is an isomer of tretinoin, the oxidized form of Vitamin A. Orthodontic tooth movement (OTM) is the result of a cascade of inflammatory responses stimulated by a physical element that is the force generated by orthodontic appliances. Isotretinoin is mainly used among adolescents and young adults, and coincidentally it is this age group that also undergoes orthodontic treatment.
Materials and Methods
Thirty-five animals were used, and they were randomly divided into 7 groups, containing 5 animals in each group. Group 1: Control; Group 2: OTM for 7 days; Group 3: OTM for 14 days; Group 4: Treated with isotretinoin for 14 days; Group 5: Treated with isotretinoin for 21 days; Group 6: Treated with isotretinoin for 14 days and undergoing OTM for 7 days; Group 7: Treated with isotretinoin for 21 days and undergoing OTM for 14 days. In Groups 6 and 7, the animals were treated with isotretinoin at a dosage of 1.0mg/kg/day for 7 days before OTM and maintained during the movement period in the respective groups.
Results
There was no significant difference on microtomographic parameters [Trabecular Volume (BV/TV), Trabecular Thickness (Tb.Th), Number of Trabeculae (Tb.N) and Trabecular Separation (Tb.Sp)] and tooth displacement between groups.
Conclusion
Isotretinoin did not cause a reduction in tooth displacement during OTM when administered at a dose of 1.0mg/kg/day and isotretinoin did not change the microtomographic parameters of animals treated with isotretinoin + OTM.
Publisher
Research Square Platform LLC
Reference38 articles.
1. Vieira, AS, Beijamini, V, Melchiors, AC. The effect of isotretinoin on triglycerides and liver aminotransferases. An. Bras. Dermatol. Rio de Janeiro. v. 87, n. 3, p. 382–387, June 2012. DOI:10.1590/S0365-05962012000300005.
2. Are there racial and sex differences in the use of oral isotretinoin for acne management in the United States?;Fleischer AB;Journal of the American Academy of Dermatology,2003
3. Acne vulgaris: a disease of Western civilization;Cordain L;Archives of dermatology,2002
4. Isotretinoin temporally regulates distinct sets of genes in patient skin;Nelson AM;The Journal of investigative dermatology,2009
5. Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action;Nelson AM;Dermatoendocrinol. 2009