Pharmacokinetics of Ethanamizuril Dispersed by Different Solvents In Chickens After Oral Administration

Abstract

Abstract In this study Ethanamizuril in different dispersants were administrated orally to target animal, chickens for pharmacokinetic study. An ultra-performance liquid chromatography method was established for sample detection and the extraction method was validated. Internal standard was used to calculate the drug concentration in chicken plasma. The results showed that the peak time of Ethanamizuril in chicken under the three dispersants was 4 ~ 5 hours, and the half-life (t1/2) of Ethanamizuril in sodium carboxymethyl cellulose solution (CMC-Na), PEG300 and Ethanamizuril solution diluted by water had a significant difference (P < 0.05) and AUC and Cmax had no significant difference which also showed no significant difference in drug exposure. AUC and Cmax were important indicators of drug exposure in toxicity studies. The study showed that different dispersants had little effect on the evaluation of toxicity studies of the drug.