Abstract
Background
A relationship between BMI (BMI ≥ 25) and periodontitis has been demonstrated in earlier research. There is an association between numerous metabolic diseases and the atherogenic index of plasma (AIP). Nevertheless, there is currently not enough data to clarify the connection between AIP and periodontitis. Analyzing the connection between AIP and periodontitis in adult US participants was the main goal of this study; its additional objective was to see if BMI (BMI ≥ 25) could mediate this relationship.
Methods
The study encompassed 3402 adults (age ≥ 30 years) diagnosed with periodontitis, treating it as a continuous factor, while distinguishing AIP as a binary variable. A variety of covariate sets were used, that include age, sex, number of flossing, and so forth. The data in this study were analyzed using a range of statistical methods, including multivariate logistic regression, subgroup analyses, and mediation effects analysis, using Empower Stats version 4.1.
Results
By using fully adjusted multivariate logistic regression analysis, a significant positive correlation between AIP and periodontitis was identified with an odds ratio (OR) of 1.12 and a 95% confidence interval (CI) of (1.01, 1.25). AIP and periodontitis were observed to be associated with a 14.78% mediating effect of BMI (BMI ≥ 25) according to mediation analysis.
Conclusion
This study indicates that a higher risk of developing periodontitis is associated with raised levels of AIP, and that BMI (BMI ≥ 25) acts as a mediating element in this connection. These results offer a fresh viewpoint on clinical strategies for managing and preventing periodontitis.