Predictive value of preoperative platelet count and D-dimer levels for spinal cord injury following acute type A aortic dissection

Abstract

Abstract Background This study aims to identify the risk factors contributing to spinal cord injury (SCI) following a type A acute aortic dissection (TA-AAD).Methods This retrospective study was conducted at a single center and involved 481 patients who received frozen elephant trunk stent implantation for TA-AAD and underwent total arch replacement with the deep hypothermic circulatory arrest at Fuwai Hospital between September 2016 and April 2020.Results The resulting data of the multivariate logistic regression analysis demonstrated that preoperative platelet count (odds ratio [OR] 0.774) and D-dimer levels (OR 2.247) held potential as independent predictors for postoperative SCI in patients diagnosed with TA-AAD.Conclusion The study results indicated that preoperative platelet count and D-dimer levels are independent risk factors for postoperative SCI in individuals with TA-AAD. This finding holds significance regarding clinical implications for prognosis and therapeutic responses in TA-AAD.