CETP Taq1B polymorphism and its association with cardiovascular risk factors in an Iranian population under angiography, A Cross-Sectional Study

Abstract

AbstractBackground:Several studies have assessed the association of the cholesterol ester transfer protein (CETP) (rs708272) TaqIB gene polymorphism with risk factors of CVDs; however, their results are inconsistent. The current study investigated the relationship between CVD risk factors and the Taq1B variant in a population from Iran that was undergoing coronary angiography.Methods:This cross-sectional study was conducted on 476 subjects aged (30-76) years of both sexes. Genotypes for Taq1B polymorphism were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) using extracted DNA from whole blood. Cardio-metabolic markers were measured by standard protocols. To determine the association between CVDs risk factors and the rs708272 variant, binary logistic regression was used in crude and adjusted models.Results:Genotype frequencies of the Taq1B polymorphism were 10.7% for B1B1, 72.3% for B1B2, and 17% for B2B2. No significant association was observed between abnormal levels of CVDs risk factors and different genotypes of the Taq1B variant, Gensini score (p= 0.64), Syntax score (p= 0.79), systolic blood pressure (p= 0.55), diastolic blood pressure (p= 0.58), waist circumference (p= 0.79). None of the abnormal serum levels were related to genotypes of the rs708272 variant. Results remained not significant after adjusting for confounders.Conclusion:Risk factors for CVDs were not associated with CETP rs708272 polymorphism in our population. Various findings reported in different populations that it suggested more studies in various regions in connection with CETP gene variants which are linked to CVD events.