Affiliation:
1. Imperial College London
2. University of Southampton
3. University of Sussex
Abstract
Abstract
We report that low level background splicing by normal genes can be used to predict the likely effect of splicing mutations upon cryptic splice site activation and exon skipping, with emphasis on the DBASS databases, BRCA1, BRCA2 and DMD. In addition we show that background RNA splice sites are also involved in pseudoexon formation, recursive splicing and aberrant splicing in cancer. We discuss how background splicing information might inform splicing therapy.
Publisher
Research Square Platform LLC
Cited by
1 articles.
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