Recurrent Cutaneous Manifestation in Multiple Myeloma: A Case Report and Management Approach

Abstract

Abstract Background Cutaneous involvement in multiple myeloma (MM) is an uncommonly encountered manifestation, more commonly observed in patients with aggressive subtypes, and often resistant to conventional therapies. Owing to its infrequency, reported clinical characteristics have been diverse and relatively nonspecific. Particularly uncommon is lower extremity involvement, where cutaneous MM is found. Case presentation In this report, we present a unique case of a middle age lady with refractory IgG lambda MM, who subsequently developed recurrent cutaneous plasmacytoma in the lower leg, while being on systemic therapy. Initially, the lesion resembled squamous cell carcinoma, posing a diagnostic challenge. Through meticulous histopathological and immunohistochemical studies, cutaneous involvement by multiple myeloma was conclusively confirmed. Conclusion This case highlights the importance of maintaining a high clinical suspicion for cutaneous MM in patients with MM who present with new skin lesions, as early diagnosis is crucial for appropriate management.