Affiliation:
1. Gansu University of Chinese Medicine
2. Gansu Provincial Hospital
3. Lanzhou University
Abstract
Abstract
Background: Observational studies suggest a possible correlation between thyroid disease and preeclampsia. However, the causal relationship between them is unclear.
OBJECTIVE: The purpose of this research was to examine at the potential links between thyroid illness and preeclampsia.
METHODS: A two-sample Mendelian randomization (MR) research was conducted using data from a genome-wide association analysis to investigate the probable causal influence of thyroid disease and preeclampsia. In this study, the inverse variance weighted (IVW) method was used as the primary result.
RESULTS: The results of the study showed that hypothyroidism (OR=3.804, 95% CI: 1.121-12.911; p=0.0321), thyroid stimulating hormone (TSH) (OR=1.128, 95% CI: 1.009-1.260; p=0.0340) were positively associated with preeclampsia. No significant association was found between genetic predisposition to hyperthyroidism and preeclampsia.
CONCLUSION: This MR study found a positive association between genetically predicted hypothyroidism, TSH and preeclampsia.
Publisher
Research Square Platform LLC
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