Investigation of the molecular mechanism of Xiangsha Liujun Pill in the treatment of gastritis based on network pharmacology and molecular docking

Abstract

AbstractXiangsha Liujun Pill (XSLJP) is a traditional Chinese medical complex prescription containing ten herbs and is widely used to treat gastrointestinal diseases. This study aims to investigate the mechanism of XSLJP treating gastritis. We first identified 327 targets based on 118 active components using the TCMSP, SwissTargetPrediction and STITCH databases and 180 gastritis-related targets using the DisGeNET database. Their intersection revealed that 26 common targets may play crucial roles in gastritis therapy by XSLJP. Then, we identified 12 key active components and eight hub proteins from the ‘drug-component-common target’ network. Finally, KEGG and GO enrichment analyses revealed that the therapeutic targets of XSLJP were mainly related to inflammation and cancer pathways, such as TNF, JAK/STAT and MAPK signalling pathway. This study not only provides new ideas for further exploring the specific mechanism of XSLJP treating gastritis but also offers a theoretical basis for future research on its active components.