DIRAS3 might function as a diagnostic biomarker and be related to immune infiltration in gliomas

Abstract

Abstract Gliomas are not composed of mere tumour cells, but a complex ecosystem with an internal immune-related component called the tumour immune microenvironment, which is closely related to the development of the tumour itself. In order to develop a novel therapy for enhancing prognosis, the goal of this study was to investigate whether DIRAS3 can impact the survival outcome of glioma patients and its potential mechanism.We extracted expression profile and clinical data from TCGA and CGGA databases to investigate the mRNA expression level of DIRAS3 in glioma patients with different clinicopathological characteristics and its effect on overall survival. Then, the expression difference of DIRAS3 in different grades of glioma and normal tissues were verified. GO, KEGG, and GSEA analyses were used to explore the possible biological functions and signal transduction pathways of DIRAS3 and its co-expressed genes. In the end, the relationship between DIRAS3 expression and immune cell infifiltration degree as well as immune-related molecules expression was also explored. Our results indicate that DIRAS3 was significantly overexpressed in gliomas and associated with poorer overall survival. It might influence the infiltration degree of multiple immune cells in the tumor microenvironment by regulating various processes of immune response.