Troponin elevation is a potential marker for patients with acute ischemic stroke in intensive care unit: a retrospective observational trial

Abstract

Abstract Background Cerebral apoplexy is an acute medical disease, and the main clinical manifestations of it are cerebral ischemia and hemorrhagic injury. Some biomarkers have been implicated as the mechanisms of ischemic stroke. Recent studies have shown that troponin is elevated in acute stroke patients. What’s more, increased plasma inflammatory cytokine levels and leukocytes have been reported in ischemic stroke. Methods Based on the previous researchs, we explored the serum levels of biochemical indicators, inflammatory cytokines as well as cardiac risk factors to further reveal the biomarkers in patients with cerebral apoplexy in or out intensive care unit (ICU) setting. At the same time, we investigated the biomarkers that related to prognosis of patients with cerebral apoplexy in ICU by multivariable logistic regression analysis. Results We found that there was no statistically significant difference in Hb, HCT, PLT, HCY, ALT, AST, Alb, BUN, CRE, UA, TAG, TC, HDL or LDL. Whereas NE and D-dimer in patients with AIS from ICU were significantly increased. In ICU, cTnl in patients who finally dead was significantly increased. Compared with patients alive, we also found that the elevated troponin is a risk factor for death in patients with acute ischemic stroke (AIS). Conclusions Due to the acute stroke patients with higher neutrophils, D dimer were more likely to enter into the ICU, cTnI elevation is associated with poor prognosis of patients in ICU. Patients with inflammation, thrombosis and elevated cTnI levels should be closely monitored and received appropriate care to improve their conditions.