Determination of 19 Fragrance Allergens in Paper Personal Care Products by Headspace SPME-GC-MS with Response Surface Methodology optimization

Abstract

Abstract Fragrance allergens (FAs), which have unique fragrances, have been widely added in wet wipes, diapers, sanitary napkins and other paper personal care products. However, their negative effects on human health and environment cannot be ignored. Meantime, there are more than 1000 FAs, and various FAs may be added in the same product. This work presented a headspace solid phase microextraction combined with GC-MS for the analysis of 19 FAs in paper personal care products, in which the factors affecting the extraction efficiency were optimized by response surface methodology. Under optimal conditions, the performance of this method has been investigated, showing good linearity (R ≥ 0.995) in the range of 2.5×10− 4-1.28×10− 1 µg as well as good precision (RSDs ≤ 20%). The proposed method exhibited the LODs within the range of 1.9×10− 6-6.0×10− 4 µg. Twenty kinds of paper personal care products were analyzed by this method, and 12 FAs including limonene, linalool, benzyl acetate, citral, citronellol, geraniol, benzyl alcohol, phenethyl alcohol, hydroxy citronellal, cinnamaldehyde, carvacrol and isoeugenol, were detected. The detection rate of benzyl alcohol was the highest (80%) with the content from 0.009 mg/kg to 5.73 mg/kg, following by linalool (over 75%) with the content up to 12.30 mg/kg in makeup remover cleansing wipes.