Abstract
This study introduces a wearable iontophoresis transdermal paper patch for delivering methotrexate, a potent anti-inflammatory drug, to treat imiquimod (IMQ)-induced psoriasis-like inflammations. This patch features a paper-based electrode that has been coated with polypyrrole and loaded with the anti-inflammatory medication methotrexate. Incorporating paper into the design enhanced the amount of drug that could be loaded and reduced its unintended release. The most effective release of the drug, was achieved with a voltage of -1.2 V. The specially designed iontophoresis patch ensured that the methotrexate optimally penetrated the mouse skin (19.7 ± 0.5 µg cm− 2 after 2 h). The patch's ability to alleviate psoriasis, which was experimentally induced in BALB/c mice (gender random), was confirmed through successful testing. Histological analysis of the skin and internal organs such as the spleen, lungs, liver, and kidneys showed that methotrexate is highly effective and has minimal adverse effects.