Pan-Cancer Analysis prove ABCD2 prognostic value and potential of immunotherapy

Abstract

Abstract The proteins encoded by the ABCD2 gene are integral members of the ATP-binding cassette (ABC) transporter superfamily. Although ABCD2 plays a critical role in membrane trafficking, its function in cancer has not been reported so far. Therefore, we undertook a systematic investigation of the prognostic implications and potential immune functions of ABCD2 across distinct tumor types. Leveraging datasets from TCGA, UALCAN, cBioPortal, and cancerSEA, we conducted an extensive series of bioinformatics analyses to elucidate the prognostic relevance of ABCD2. Our findings revealed statistically significant differences in ABCD2 expression between most tumors and adjacent normal tissues. Furthermore, ABCD2 exhibited both positive and negative associations with the prognosis of various cancers.Intriguingly, GSEA enrichment analysis underscored a strong correlation between ABCD2 and immune-related functions. To validate this observation, we investigated the relationship between the transcription of ABCD2 and immune cells, and the results revealed a significant correlation between ABCD2 and various immune cells, such as B cells and natural killer cells.To elucidate the biological significance of ABCD2 in tumor development, we delved into single-cell sequencing data, gene mutations, and promoter methylation patterns. Lastly, our study identified two potential ABCD2-targeted drugs. Altogether, our findings position ABCD2 as a versatile prognostic marker across multiple malignancies and highlight its paramount importance in the realm of tumor immunotherapy.