Comparison of clinical and pathological characteristics between localized giant cell and fibroadenoma of tendon sheath

Author:

Jin Linfang,Wang Shuai,Zhang Ya

Abstract

Abstract

Objective: To explore the clinical and pathological characteristics of localized giant cell tumor of tendon sheath (L-GCTS) and fibroma of tendon sheath (FTS), and to compare and analyze them. Methods: 241 cases of L-GCTS and 41 cases of FTS who underwent surgical resection and diagnosis at Wuxi Ninth People's Hospital from 2019 to 2023 were collected. Clinical and pathological data of all cases were organized for retrospective analysis. Chi-square test was used to analyze differences between groups. Results: Comparing our two groups of cases, we found that L-GCTS is more common, while FTS is less common. However, the two were very similar in clinical features, disease course, age of onset, tumor size and overall appearance, as well as imaging manifestations; In our case, L-GCTS was more common in female patients, and there was no significant gender difference in FTS; L-GCTS was more common in the right hand, FTS was also more common in the hand, but the left incidence rate is slightly higher than the right, with no significant difference; In addition, a small number of L-GCTS were accompanied by damage to surrounding tissues, and 41 cases of FTS did not cause damage to surrounding tissues; L-GCTS and FTS are mostly single lesions, with a few being multiple lesions; Among 241 cases of L-GCTS, 235 were primary cases, 6 were recurrent cases, and 41 cases of FTS were all primary cases; The coincidence rate between preoperative imaging diagnosis and postoperative pathological diagnosis of L-GCTS was 89%, and the coincidence rate between preoperative imaging diagnosis and postoperative pathological diagnosis of FTS was 55.3%. The main reason was that it is easier to misdiagnose FTS as L-GCTS before surgery; There were certain differences in pathological and immunohistochemical manifestations between the two. Conclusion: L-GCTS and FTS are very similar in clinical features, disease course, predilection site, predilection age, tumor size, and tumor appearance. Imaging examination methods are difficult to distinguish between the two before surgery. The differentiation between the two mainly relies on histopathology and immunohistochemistry, and the two also exhibit different molecular genetics. Although both L-GCTS and FTS are benign tumors, their recurrence rates and other prognostic factors are different. Therefore, it is necessary to clearly distinguish between the two.

Publisher

Springer Science and Business Media LLC

Reference25 articles.

1. de St. Aubain Somerhausen N, van de Rijn M. The WHO Classification of Tumours Editorial Board. WHO Classification of Tumours Soft Tissue and Bone Tumours. 5thed. Lyon: IARC; 2020. pp. 133–6.

2. Johannes Haybaeck, Zhi-Hui Yang.Giant cell tumor of tendon sheath: A report of 216 cases;Huang C-G;J Cutan Pathol,2023

3. Hüseyin B Çevik, Kayahan S, Eceviz E. Seyit Ali Gümüştaş. Tenosynovial Giant Cell Tumor in the Hand: Experience with 173 Cases. J Hand Surg Asian Pac Vol 2020;25(2):158–163.

4. Giant cell tumor of tendon sheath in the hand: analysis of risk factors for recurrence in 50 cases;Ozben H;BMC Musculoskelet Disord,2019

5. Fibroma of tendon sheath;Chung EB;Comp Study Cancer,1979

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3