Affiliation:
1. University of California Los Angeles
2. UCLA
Abstract
Abstract
We investigated the relationship between neighborhood disadvantage (area deprivation index [ADI]) and intracortical myelination (T1-weighted/T2-weighted ratio at deep to superficial cortical levels), and the potential mediating role of the body mass index (BMI) and perceived stress in 92 adults. Worse ADI was correlated with increased BMI and perceived stress (p's<.05). Non-rotated partial least squares analysis revealed associations between worse ADI and decreased myelination in middle/deep cortex in supramarginal, temporal, and primary motor regions and increased myelination in superficial cortex in medial prefrontal and cingulate regions (p<.001); thus, neighborhood disadvantage may influence the flexibility of information processing involved in reward, emotion regulation, and cognition. Structural equation modelling revealed increased BMI as partially mediating the relationship between worse ADI and observed myelination increases (p=.02). Further, trans-fatty acid intake was correlated with observed myelination increases (p=.03), suggesting the importance of dietary quality. These data further suggest ramifications of neighborhood disadvantage on brain health.
Publisher
Research Square Platform LLC
Reference69 articles.
1. Kim P, Evans GW, Chen E, Miller G, Seeman T. How Socioeconomic Disadvantages Get Under the Skin and into the Brain to Influence Health Development Across the Lifespan. In: Handbook of Life Course Health Development (eds Halfon N, Forrest CB, Lerner RM, Faustman EM) (2018).
2. Association of Neighborhood-Level Disadvantage With Cerebral and Hippocampal Volume;Hunt JFV,;JAMA Neurol,2020
3. Neighborhoods, obesity, and diabetes–a randomized social experiment;Ludwig J,;N Engl J Med,2011
4. Running to the store? The relationship between neighborhood environments and the risk of obesity;Zick CD;Soc Sci Med,2009
5. Obesogenic neighborhood environments, child and parent obesity: the Neighborhood Impact on Kids study;Saelens BE,;Am J Prev Med,2012