Ovarian treatment with Autologous Platelet-Rich Plasma plus autologous Bone Marrow-derived Stem cells. Case series

Abstract

Introduction: There are limited treatment options for women with severely diminished ovarian reserve (DOR) who experience repeatedly failed in vitro fertilization (IVF) cycles. Therefore, most patients resort to using donor oocytes. Ovarian rejuvenation is an innovative procedure intended to reactivate the remaining follicles in the ovary to improve ovarian response in assisted reproduction treatments. Case presentation: Using two treatments at the same time, we enhance the effects of intraovarian platelet-rich plasma (PRP) injection and Autologous Bone Marrow-Derived Mesenchymal Stem Cells on ovarian stimulation outcomes in three women referred to a Uruguayan IVF center. Conclusion: Data presented herein suggest that autologous intraovarian PRP infusion plus Stem Cells may restore ovarian function. This may enable the achievement of pregnancy. However, the occurrence of spontaneous pregnancy, clinical pregnancy and live birth reflect a significant change. Longer follow-up may detect a functional recovery with improvement of the ovarian reserve hormone markers.