Salbutamol and Epinephrine Inhalation as a Conservative Treatment of Transient Tachypnea of Newborn: a Pilot Randomized Controlled Trial

Abstract

Abstract Objective: To evaluate the efficacy and the safety of inhaled salbutamol and epinephrine in the treatment of TTN. Design: Double-blinded randomized control pilot study was carried out on 135 near and full-term infants with TTN in the NICU of Mansoura University children's hospital. They were randomly assigned to receive either a single dose of epinephrine, salbutamol, or placebo inhalation. The primary outcome was the level of TTN Downe’s score and the required respiratory support. PaO2 and PaCO2, duration of oxygen therapy, hospital stay, and the adverse effects were considered secondary outcomes. registered at www.clinicaltrials.gov (NCT05006235). Results: Downe’s score, CPAP requirement, and PaCO2 were significantly less in the salbutamol and epinephrine groups, in addition to a shorter duration of oxygen support and hospital stay with tolerable adverse effects. Conclusion: Epinephrine or salbutamol inhalation in treatment of TTN is safe, well tolerated, and effective in reduction of the severity of respiratory distress.