Beneficial Impact of Aerobic Exercise During Pregnancy on Motor Coordination Deficits Induced by PTZ in Preadolescent Male Mice

Author:

Sabaghi Ayoob1,Yousofvand Namdar1

Affiliation:

1. Razi University

Abstract

Abstract Objective Seizures during pregnancy have been linked to adverse outcomes for newborns and motor coordination (MC) defects in offspring. Physical activity has shown promise in reducing seizure severity and promoting positive outcomes for newborns. In this study, we investigated the impact of aerobic exercise during pregnancy on seizure activity in pregnant mice treated with pentylenetetrazole (PTZ) and the MC of preadolescence male mice.Methods Adult female ICR mice were divided into two groups and administered PTZ or saline for 30 days before mating. PTZ treatment continued throughout pregnancy for the experimental group, while the control group received saline. Active pregnant mice engaged in aerobic treadmill exercises from the first to the 20th day of pregnancy. MC in preadolescence male offspring was assessed using the rotarod test.Results Prenatal exposure to maternal seizures induced by PTZ resulted in MC deficiencies in preadolescence male offspring (P < 0.05). Aerobic exercise during pregnancy demonstrated beneficial effects on convulsive activity (P < 0.05) and was able to counteract the MC deficits caused by maternal seizures during pregnancy.Conclusion These findings suggest aerobic exercise during pregnancy may serve as a supplementary therapeutic approach to reduce convulsive activity and mitigate MC impairments in preadolescence male offspring.

Publisher

Research Square Platform LLC

Reference78 articles.

1. Mafla-Mendoza, A.P., E.D. Paredes-Urbano, and E. Gea-Izquierdo, Risk Factors Associated with Epilepsy Related to Cerebrovascular Disease: A Systematic Review and Meta-Analysis. Neuropsychiatric Disease and Treatment, 2023: p. 2841–2856.

2. Pharmacological and therapeutic approaches in the treatment of epilepsy;Ghosh S;Biomedicines,2021

3. Epilepsy in Africa: a multifaceted perspective on diagnosis, treatment, and community support;Kassahun Bekele B;Ann Med Surg (Lond),2024

4. Effects of maternal use of antiseizure medications on child development;Meador KJ;Neurologic clinics,2022

5. Effects of prenatal seizures on cognitive and motor performance in mice offspring (with emphasis on BDNF and GDNF levels);Sabaghi A;Neurophysiology,2018

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3