A case of herpes simplex virus induced peripheral neuropathy and encephalitis with positive GM3 and CASPR2 antibody

Author:

Lu Hongji1,Liao Yingdi2,Zhang Changlin3,Wen Wanxing1,Du Yaming4,Zhao Ming5,Wang Lixing1

Affiliation:

1. The Neurological Intensive Care Unit of Guangdong Provincial Hospital of Chinese Medicine

2. Kunming Municipal Hospital of Traditional Chinese Medicine

3. Department of Stroke Center, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine

4. Guangzhou University of Chinese Medicine

5. The Encephallopathy Department.1 of Guangdong Provincial Hospital of Chinese Medicine

Abstract

Abstract Background: We reported on a case involving an older patient with HSV-1 encephalitis who simultaneously experienced the onset of peripheral nerve symptoms associated with the presence of anti-GM3 immunoglobulin G (IgG). Case presentation: A 77-year-old male was admitted to hospital with high fever, weakness of both lower limbs, and an unstable gait. A CSF test revealed a strikingly increased protein level (1,002 mg/L) and MRI revealed hyper-signal lesions in the right temporal lobe, right hippocampus, right insula, and right cingulate gyrus. The CSF was positive for HSV PCR (HSV-1,17870). In addition, the serum samples were positive for CASPR2 antibodies (1/10) and anti-GM3 immunoglobulin G (IgG) (+). The patient was diagnosed with HSV-1-induced peripheral nerve symptoms that were associated with encephalitis and the presence of anti-GM3 IgG and anti-CASPR2 antibodies. The patient had received included intravenous immunoglobulin, intravenous acyclovir, and corticosteroids therapy. At the one-year follow-up examination, he had regained the necessary skills associated with daily life. Conclusions: Herpes simplex virus infection often induces encephalitis, and reaction to the virus may trigger an autoimmune response. Early diagnosis and treatment can avoid the progression of the disease to include autoimmune encephalitis.

Publisher

Research Square Platform LLC

Reference18 articles.

1. Herpes virus infection of the peripheral nervous system;Steiner I;Handb Clin Neurol,2013

2. The neurotropic herpes viruses: herpes simplex and varicella-zoster;Steiner I;Lancet Neurol,2007

3. 1016/S1474-4422(07)70267-3.

4. Hjalmarsson A, Blomqvist P, Sköldenberg B. Herpes simplex encephalitis in.

5. Sweden. 1990–2001: incidence, morbidity, and mortality. Clin Infect Dis; 2007.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3