Affiliation:
1. Universidade da Beira Interior, Covilha, Portugal
Abstract
Is it possible to characterize the SARS-CoV-2 viral infection by analyzing
the viral hijacking of cellular metabolism for its reproduction and
multiplication? Gibbs free energy appears to be the critical factor of
successful virus infection. A virus always has a more negative Gibbs free
energy of growth than its host. Hence, the synthesis of viral components is
thermodynamically favourable. On the other side, it could be essential to
better thermodynamically understand how S1 and S2 spike protein interacts
with the ACE2 receptors and the cell membrane more efficiently than the
usual nutrients, which are intercepted. Gibbs energy gives a static model,
which does not include the time arrow of viral evolution. A better
comprehension of this evolutional path could require an accurate analysis of
entropy generation or exergy disruption of binding, replication, and
multiplication.
Publisher
National Library of Serbia
Subject
Renewable Energy, Sustainability and the Environment
Cited by
5 articles.
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